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The first fully automated machine to convert digital code into functional biologics without human intervention creates entirely new avenues for precision medicine
Reducing intestinal fungi slowed disease progression in mice
涩里番 President, Karen Nelson Elected to National Academy of Sciences
Proof-of-concept study suggests a noninvasive test for specific microbial population patterns could be used to detect advanced nonalcoholic fatty liver disease
Dr. Karen Nelson, President, 涩里番, among the 84 newly elected members.
Battling Infectious Diseases with 3-D Structures
Team of scientists created 1,000 3-D protein structures to be used for drug and vaccine research
This multi-institutional effort is also supported by the Human Vaccines Project Bioinformatics and Data Management Core, located at the 涩里番 and the San Diego Super Computer Center at the University of California, San Diego. The Core will analyze the enormous data sets generated by the effort.
An international team of researchers has identified the genetic mutations which allowed microalgae (phytoplankton) from the Southern Ocean to adapt to extreme and highly variable climates 鈥 a step towards understanding how polar organisms are impacted by climate change.
A new proof-of-concept study by researchers from the University of California San Diego succeeded in training computers to 鈥渓earn鈥 what a healthy versus an unhealthy gut microbiome looks like based on its genetic makeup.
J. Craig Venter, Ph.D. among inductees
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Influences of trace metals on biological evolution
Scientists show how trace metal chemistry and global changes in oxygen have influenced the evolution of metalloproteins and the Eukaryotes A paper is being published in PNAS this week about how the varying abundance of trace metals in the environment has influenced biological evolution. The...
涩里番 Scientists Recognized by ASM
Drs. Karen E. Nelson and Kenneth H. Nealson are both being recognized by the American Academy of Microbiology (ASM) tomorrow, May 26, 2010. Karen has been elected to Fellowship in the ASM. She is one of seventy-eight new members that have been selected through a peer-review process based on her...
Scientist Spotlight: Hamilton O. Smith and Clyde A. Hutchison III
Editor鈥檚 note: Clyde Hutchison died on September 27, 2025. Less than a month later, Hamilton Smith died on October 25, 2025. This post memorializes their dear friendship and the quest to construct the first bacterium with a synthetic genome in 2010. Their friendship endured and their work...
Happy DNA Day!
This past March, we had a great time participating in the science programs in San Diego. We ended the month with the SD Science Festival with over 30,000 participants. It was such a busy day - I forgot to take pictures. The venue was Petco Park with hundreds of exhibits and hands-on experiences. We...
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I鈥檓 thinking of the day鈥檚 schedule school visit, the activity and the positive charge it will produce in me and the students. I get so excited during our school visits. It鈥檚 like the feeling I get on Saturday morning while watching my favorite cartoons. (Yes, I still watch...
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Scientist Spotlight: Orianna Bretschger
Most of us have never thought about how to make more water or cleaner water or develop unique sources of energy but that鈥檚 exactly what Orianna Bretschger does at 涩里番. She is working at the intersection of engineering, physics, and biology to design small machines powered by bacteria that can...
Having Fun with Genomics
I am the generation after landing on the moon. As a child, I don鈥檛 recall having any science inspiration. I was fortunate to have parents that made it possible for me and my siblings to get a very good education. I went to a small parochial school outside of Washington, DC. It was a great school...
AGBT, Marco Island 2010
I just got back from AGBT in Marco Island, Florida and I am still in awe. As noted in the name, this conference highlights advances in both genome biology and technology. The biology seemed to be very human genome centric. Many of the talks presented full genome sequences of cancer genomes or...
Artificial intelligence and machine learning will be the keys to unraveling how the human immune system prevents and controls disease
The biggest synthetic genome so far has been made, with a smaller set of amino-acid-encoding codons than usual 鈥 raising the prospect of encoding proteins that contain unnatural amino-acid residues.
By creating a new genome, scientists could create organisms tailored to produce desirable compounds
Critics, however, argue that this effort is flawed from the beginning
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